NUWIQ Convenient and Flexible Dosing

NUWIQ offers physicians and nurses the convenience of flexible dosing for children and adults, and a wide range of dosage strength vials with the lowest, 2.5 ml diluent volume among currently approved FVIII products.

NUWIQ dosing for routine prophylaxis in children and adults1

Patients Dose (IU/kg) Frequency of Infusions
Adolescents (12-17) and adults 30-40 Every other day
Children (2-11 years) 30-50 Every other day or 3 times per week

NUWIQ dosing for on-demand treatment and control of bleeding in children and adults

Type of Bleeding Episodes Required Peak Post-Infusion factor VIII Activity (% of Normal or IU/dL) Frequency of Dosing (hours) Duration of Therapy (days)
Minor
Superficial muscle or soft tissue and oral bleeds
20-40 12-24 At least 1 day, until the bleeding episode of resolved
Moderate to Major
Hemorrhage into muscles, unto oral cavity, hermarthrosis, known trauma
30-60 12-24 for 3-4 days or more until the bleeding episode is resolved
Life-Threatening
Intracranial, intra-abdominal, gastrointestinal or intrathoracic bleeds, central nervous system bleeds, bleeding in retropharyngeal spaces or ilioposas sheath, eyes, retina, fractures, or head trauma.
60-100 8-24 Until bleeding risk is resolved

 

Dosing Flexibility with NUWIQ

NUWIQ dosages
  • NUWIQ offers a broad range of dosage strengths with the lowest, 2.5 ml diluent volume among currently approved FVIII products.
  • Available in 250 IU, 500 IU, 1000 IU, 2000 IU, 2500 IU, 3000 IU, and 4000 IU vials
  • Larger single-dose vials of 2500, 3000 and 4000 IU offer greater flexibility and convenience for patients requiring larger volumes of FVIII.
  • All NUWIQ vial sizes are reconstituted with an easy-to-use 2.5 ml syringe, pre-filled with water for injection.
  • Each NUWIQ box comes with a vial adapter, butterfly needle, and alcohol swabs in addition to the NUWIQ vial and pre-filled syringe.

NUWIQ device and packaging

Storing NUWIQ

  • Keep NUWIQ in its original box in the refrigerator to protect it from exposure to light
    • NUWIQ can be stored in the refrigerator for up to 24 months at 36-46°F (2-8°C)
    • NUWIQ can be kept at room temperature (up to 77°F [25°C]) for a single period not exceeding 3 months
    • After being stored at room temperature, NUWIQ must not be put back into the refrigerator
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Find out if personalized prophylaxis with NUWIQ is right for your patients.

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References

1. NUWIQ Full Prescribing Information. Hoboken, NJ: Octapharma USA, Inc.; 2015.